+1 @Gritmonger and thread
Adding to the idea of seasons on a global scale, climate conditions should also be dependent on where in the world you are. E.g. Locations closer to the equator don't really have a "Winter" so much as wet and dry seasons. This also has an impact on species able to survive there. Tropical plants would also grow faster than temperate and cold climate plants.
It sounds like tropical living would be a big bonus, but a down side could be that building maintenance may increase slightly due to increased moisture/humidity effects, not to mention cyclones/hurricanes and monsoonal rains washing away unsecured topsoil.
The effects of exhaustion in humidity may also make construction slower. Air conditioning could help but then there's the increased energy requirements of this, as well as possible production of greenhouse gases or waste products.
It really depends on what, and how many, real world conditions are wanted [at least initially]. Too many factors and the game becomes too hard to get started.